The results showed that the levels of MIF, VACM-1 and mAIb/Cr in the observation group were significantly lower than those in the control group (P<0.05), and the level of SERP-5 in the observation group was significantly higher than that in the control group (P<0.05), suggesting that atorvastatin could relieve the renal function damage and renal fibrosis of DN patients better than the conventional treatment. Here, CUL5 is linked to liver dysplastic nodule.