The results shown above indicate that extracts L. lactis expressing rIFN-Ia (strain MT006) stimulate the expression of antiviral genes (Mx and PKR) in CHSE-214 and reduce the viral load in the supernatant in SHK-1 cell cultures, suggesting that this strain could help control infections by IPNV or other viruses sensitive to IFN-Ia. This evidence concerns the gene EIF2AK2 and infection.