Recent studies showed that PTK7 is overexpressed in triple-negative breast cancer (TNBC), non-small-cell lung cancer (NSCLC), ovarian cancer (OVCA), cervical cancer, esophageal squamous cell carcinoma (ESCC), and hepatocellular carcinoma (HCC) and enriched in tumor-initiating cells (TICs) from TNBC, OVCA, and NSCLC patient-derived xenografts (PDXs), and its overexpression is associated with poor survival in NSCLC, cervical cancer, ESCC, and HCC (12, 17–22). This evidence concerns the gene PTK7 and hepatocellular carcinoma.