Although ROR1-CAR T cells (derived from R12- and 2A-scFv) without cross-reactivity with murine ROR1 exhibited no evident toxicity in NSG mice tumor model, murine ROR1-specific CAR T cells (derived from R11-scFv) induced lethal bone marrow failure due to recognition of ROR1+ stromal cells, which can be rescued by the logic-Gated strategy of CAR construction (38, 40). The gene discussed is ROR1; the disease is neoplasm.