In the CD4+CD45RBhigh T-cell-transferred colitis model, IFN-γ-producing effector T (Teff) cells including conventional T helper 1 (Th1) cells and IFN-γ/IL-17-co-expressing T helper 17 (IFN-γ-producing Th17) cells are responsible for the pathogenesis (Powrie et al., 1993; Sujino et al., 2011). The gene discussed is CD4; the disease is colitis.