Per Li et al. (2016) inquiry into the benefits of DMDD against high-fat diet (HFD)-evoked obesity and insulin resistance in mice, DMDD (at daily doses of 12.5, 25, and 50 mg/kg, i.g. for 28 days) markedly decreased body and adipose tissue weights and reduced insulin, blood glucose, TC, TG, FFA, IL-6, and TNF-α levels in serum. Here, INS is linked to Insulin resistance.