In Zhang et al. (2020) study of the antidiabetic activity of DMDD isolated from A. carambola roots in Wild type and TLR4 knockout mice with diabetic kidney disease, DMDD (at daily doses of 12.5, 25, and 50 mg/kg, i.g. for 28 days) caused notable reductions in urinary albumin, TC, TG, LDL-C, FBG, and CysC levels. This evidence concerns the gene TLR4 and diabetic kidney disease.