NFKB1 and breast cancer: Gao et al. (2015) also showed that DMDD significantly suppressed breast cancer MCF-7 and BT20 cell growth, with the IC50 values ranging from 3.13 to 5.57 μM; DMDD exerted anticancer traits by inducing apoptosis and blocking the cell cycle at the G1 phase, increasing the generation of intracellular ROS, which activated the extrinsic receptor and intrinsic mitochondrial pathways and inhibited NF-κB activation.