INS and liver dysplastic nodule: While LGP1 markedly alleviated the histopathological changes in the kidney and lowered FBG, FINS, and insulin sensitivity index (ISI) levels and caspase-3/8/9, Bax, and NF-κB protein expressions, LGP2 had no impact (Wen et al., 2013), suggesting that LGP1 could attenuate and treat the progression of DN through regulating several molecular targets.