APP and dementia: The control of cholesterol levels is essential in midlife because high cholesterol level appears to be a risk factor for dementia (McFarlane and Kedziora-Kornatowska, 2020), especially AD (Shobab et al., 2005) as suggested by in vitro studies because it is implicated in reducing the production of soluble amyloid precursor protein and the modulating α-secretease cleavage of amyloid precursor protein production (Tsatsanis et al., 2020).