OCLN and hematocrit: In the present clinical study of patients with acute ischemic stroke, serum occludin levels were significantly higher in the HT group (both HI and PH subgroups) than the non-HT group, suggesting that elevated occludin levels were related with the extent of BBB damage, and that serum occludin could predict the risk of secondary HT following reperfusion treatment (Li et al., 2020).