Table-1 presents the values of HSP 90, iNOS, and VEGF expressions in the skin of rats with alloxan-induced DM. A positive correlation (r=0.65, p=0.01) was detected between the mean blood glucose level on day 28 and the expression levels of HSP 90, iNOS, and VEGF in diabetic rats. There was a significant difference in the skin expressions of HSP 90, iNOS, and VEGF between Groups 1 and 2 (Figures-1-3). Here, NOS2 is linked to diabetes mellitus.