APP and amyloidosis: The decrease in newborn neurons was more acute in hAPPwt (the line I5 we used in the present paper) compared to a similar model of APP overexpression, the hAPP-J20 mouse line, that overexpresses APP with a Swedish-Indiana mutation and exhibits high Aβ levels with amyloid plaque formation, therefore suggesting that hAPP itself more than Aβ is an important factor inhibiting adult neurogenesis44,62.