The heatmap showed that more than half of the genes were downregulated in tumor tissue, and consistent with the univariate Cox regression analysis, they represented a better prognosis, including PTGS2, ACO1, DPP4, CRYAB, PRKCA, ACSL4 and AKR1C3 (Fig. 2E). The gene discussed is PRKCA; the disease is neoplasm.