We also found that although CXXC5 expression is significantly deregulated, there is no strong correlation between the CXXC5 and MeCP2 expressions in healthy mammary tissue in paired normal breast samples and breast tumors (Supplementary Information Fig. S14c–e), neither in many other tissue tumors including acute myeloid leukemia, brain lower grade glioma, glioblastoma multiforme, sarcoma, prostate adenocarcinoma, and testicular germ cell carcinoma (Supplementary Information, Fig. S15). Here, CXXC5 is linked to breast neoplasm.