There was a significant difference between CF and non-CF serum concentrations for 6 of the 12 general inflammatory markers, with MIP-2, IL-27p28, IP-10, IL-22, and IL-16 demonstrating a significant increase when compared to the non-CF controls (p < 0.050, Fig. 3a,b). The gene discussed is IL22; the disease is cystic fibrosis.