Our previous study showed that c-Abl mediated paxillin tyrosine phosphorylation at Y31 and Y118 regulates LPS-induced endothelial dysfunction and lung injury13; however, the underlying molecular mechanism(s) by which paxillin regulates mitochondria (mt)-derived ROS dependent endothelial dysfunction is unknown. The gene discussed is ABL1; the disease is endothelial dysfunction.