These results indicated that the mRNA expression of ZIC1/5 was a significant independent prognostic predictor for OS in LGG patients, and the mRNA expression of ZIC3 was related to GBM patient prognosis, which suggested that ZIC1/5 and ZIC3 are independent prognostic factors in LGG and GBM patients, individually. This evidence concerns the gene ZIC1 and glioblastoma.