CAT and cancer: Once the FIGs-LC endocytosed by cancer cells, abundant stable O2 nanobubbles were primarily produced by CAT and H2O2 level was increased under the catalysis oxidation by LOx based on the lactate (2.0 mM)/H2O2(100 μM)-containing mimic culture medium, thereby promoting the ·OH and 1O2 generation and eventually induce the cell death.