CAT and neoplasm: In this cascade catalytic system, the utilization of endogenous H2O2 can alleviate oxygen deficiency by CAT biocatalytic conversion on one side, and the reduced oxygen consumption of tumor cells through LOx-CAT cascade biocatalytic conversion of lactate coupling with the pyruvate cycle can be achieved, because the decrease of NADH can counteract the O2 consumption in the later oxidative phosphorylation, as shown in Supplementary Fig. 1.