Here we not only report a role of NAS1 to promote metastatic dormancy of breast cancer, consistent with the recent study39 but also reveal a previously unidentified functional mechanism of NAS1, by which NAS1 binds to the GC-rich 5′UTR area of NR2F1 mRNA and recruits PTBP1 to enhance the IRES-dependent translation of NR2F1. This evidence concerns the gene NR2F1 and breast carcinoma.