More importantly, when CA1h-P2 cells were inoculated into the mice, NR2F1 overexpression abrogated the effect of NAS1 knockdown and inhibited tumor cell proliferation after seeding (Fig. 4g), leading to reduced metastatic outgrowth and formation of tumor nodules in lungs (Fig. 4h, i). This evidence concerns the gene NR2F1 and neoplasm.