It is mediated by the receptor-interacting protein kinase-1 (RIPK1), and its substrate, mixed lineage kinase domain-like (MLKL) [4, 5], and it has been implicated in several human pathologies such as chronic inflammatory diseases (e.g., inflammatory bowel disease and Chron’s disease), and neurodegenerative diseases (Alzheimer’s, Parkinson’s and amyotrophic lateral sclerosis) [6, 7]. The gene discussed is RIPK1; the disease is amyotrophic lateral sclerosis.