In our independent replication datasets, both variants near C9ORF72 significantly associated with increased risk for FTD (rs117204439 MAF-cases = 3.6%; MAF-controls = 1.5%; P = 2.0 × 10−3; OR = 3.2, rs147211831 MAF-cases = 3.1%; MAF-controls = 1.1%; OR = 3.95, P = 1.1 × 10−3) (Table 1). This evidence concerns the gene C9orf72 and frontotemporal dementia.