A single intronic variant in a locus on chromosome 5 (rs76679949), located on the SLIT3 (Slit Guidance Ligand 3) gene, was associated with a 3.7 times increased risk of FTD (MAF-cases = 4.4%; MAF-controls=1.9%; P = 1.4 × 10−8) (Fig. S5). Here, SLIT3 is linked to frontotemporal dementia.