In this manuscript entitled “Photoreceptor cKO of OTX2 enhances OTX2 intercellular transfer in the retina and causes photophobia", the authors studied the cell-autonomous function of the homeoprotein OTX2 in PRs by deleting specifically Otx2 in adult rod and cone PRs using Crx-CreERT2. The gene discussed is OTX2; the disease is Photophobia.