The paper titled “Seizure phenotype and underlying cellular defects in Drosophila knock-in models of DS (R1648C) and GEFS+ (R1648H) SCN1A epilepsy” is focused on characterizing two mutations at the same position in SCN1A, R1648C and R1648H, and their role in epilepsy. This evidence concerns the gene SCN1A and Seizure.