CXCL2 and neoplasm: Previous studies reported CXCL2/CXCR2 axis played a significant role in promoting neutrophils and endothelial cells' chemotaxis, resulting in tumor growth, angiogenesis, chemoresistance, and transformation [27–29]. Makoto et al. suggested omental adipocytes triggered gastric cancer cells proliferation, migration and angiogenesis induction by CXCL2 secretion [30].