A previous study also identified two naturally-occurring mutations (Val514Ala and Ala575Val) in a woman with primary amenorrhea and ovarian hyperstimulation syndrome (OHSS); the study showed that a dose-dependent increase in cAMP levels upon FSH stimulation was not observed in case of the Ala575Val-expressing mutant [25]. This evidence concerns the gene BRD2 and ovarian hyperstimulation syndrome.