The allelic variant, A307T in hFSHR (equivalent to A306T in eFSHR) was first reported in the extracellular domain following screening of the FSHR gene in patients with hypogonadotropic ovarian dysgenesis (ODG) [1,6], premature ovarian failure (POF) [17], women with hypogonadotropic hypogonadism, and in infertile men [13]. The gene discussed is FSHR; the disease is primary ovarian failure.