NR3C1 and neoplasm: Unbiased canonical pathway analysis (Ingenuity Pathway Analysis (IPA, Qiagen)) of the biological processes most enriched during R. equi infection showed strong upregulation of genes related to innate immune signaling (“Role of pattern recognition receptors in recognition of bacteria and viruses”, “Interferon signaling”, “Glucocorticoid receptor signaling”), cell death (“Death receptor signaling”), and tumor pathogenesis (“Tumor microenvironment pathway”) (Fig 2E).