We also observed that the expression of chemokine receptors responsible for pDC localization to infected peripheral tissues, such as CXCR3 and CXCR4, or for their lymph node homing, as CCR7 and CD62-L, was induced by SARS-CoV-2 natural infection both in terms of frequency and surface expression levels in cells of both asymptomatic or severe COVID-19 patients, possibly indicating that these cells are committed to migrate to the sites of viral infection independently of the degree of disease severity. The gene discussed is CXCR4; the disease is viral infectious disease.