Further, we proved that SARS-CoV-2-mediated release of inflammatory cytokines and chemokines heavily relies on the TLR-7/8 signaling and requires stimulation with infectious live SARS-CoV-2 virions, consistently with recently published evidences of SARS-CoV-2 partially productive infection of lymphomononuclear cell subsets [28,51]. Here, TLR7 is linked to infection.