In our study we observed that SARS-CoV-2 infection of the lung carcinoma epithelial cell line Calu-3 triggers IL-6 expression while was unable to induce Mx1 gene expression, suggestive of a strong reduction of type I IFN production (Fig 3A) and, thus, confirming what already observed [7,22]. This evidence concerns the gene MX1 and lung carcinoma.