Given that G-MDSCs can induce T cell anergy through PD-L1–PD-1 interaction [31] and that PD-L1+ neutrophils are expanded during COVID-19 [35], it raises the possibility that PD-L1+G-MDSCs can induce T cell anergy through the interaction of PD-L1–PD1. The gene discussed is CD274; the disease is COVID-19.