CD4 and COVID-19: Whereas 2 studies determined that the numbers of suppressive CD16+LOX1+ G-MDSCs in circulation were increased during severe COVID-19 and constituted a strong predictor of disease severity [36,37], a third study showed that the expansion of CD10neg immature neutrophils is associated with decreased numbers of CD4+ T cells, CD8+ T cells, VD1 T cells, and VD2 T cells in circulation, increased cytokine production, and disease severity [38].