Results also revealed that down-regulation of CXCL12 [HR: 1.1, p>0.05] and up-regulations of CXCL8 [HR: 0.61, p>0.05], AGT [HR: 0.64, p>0.05], GNB1 [HR: 0.57, p<0.05], and, CXCL1 [HR: 0.69, p<0.05] are the bad prognostic biomarkers for predicting the OS duration of the COAD patients as they do not correlated with the reduced OS duration (Fig 13). Here, GNB1 is linked to colon adenocarcinoma.