The real hub gene Chemokine (C-X-C motif) ligand 1 (CXCL1), also known as GRO-α, belongs to the G protein-coupled receptor family that specifically binds to the CXC chemokine receptor 2 which activate the RAS (Rat sarcoma) pathway in cell proliferation [74]. Here, ACKR3 is linked to sarcoma.