The OS survival analysis of the real hub genes demonstrated that high expression of GNG4 was the good prognostic biomarkers while CXCL12, CXCL8, AGT, GNB1, and CXCL1 were the bad prognostic biomarkers for predicting the OS duration of COAD patients. This evidence concerns the gene CXCL12 and colon adenocarcinoma.