In view of our findings, we speculate that four real hub genes (CXCL8, CXCL12, CXCL1, and GNB1) function as an oncogenes and down-regulation of mir-1-3p may lead to the up-regulation of these genes as a different axis (mir-1-3p/CXCL8 or CXCL12, CXCL1, and GNB1) in the pathogenesis of CRC. Here, CXCL8 is linked to colorectal carcinoma.