TP53 and colorectal carcinoma: Genetic mutations and altered expression levels of various tumor suppressor genes including Adenomatous Polyposis Coli (APC), Tumor Protein 53 (TP53) and BReast CAncer gene (BRCA1) have long been considered as an important cause of CRC, which affect the development, progression, and metastasis of CRC through a variety of regulatory pathways [2].