Loss of the SORBS2 protein in mouse results in phenotypes characteristic of human arrhythmogenic right ventricular cardiomyopathy (ARVC), including dilated right ventricle (RV), RV dysfunction, spontaneous ventricular tachycardia (VT), and premature death [30]. The gene discussed is SORBS2; the disease is arrhythmogenic right ventricular cardiomyopathy.