Perhaps the previous observation in cultured gastric mucosal cells that raising the glucose concentration in the cell culture medium from 5 mM (representative of normoglycemia) to 10 mM (representative of hyperglycemia) reduces ghrelin release only minimally, whereas lowering it from 5 mM to 1 mM (representative of hypoglycemia) or to 0 mM enhances ghrelin release, alludes to a minimal role for a direct inhibitory effect of glucose on ghrelin secretion in vivo (35). The gene discussed is GHRL; the disease is Hyperglycemia.