This approach has since been used to rapidly quantify the number of detergent insoluble inclusions across many in vitro models expressing aggregation-prone proteins, including mutant huntingtin (linked with Huntington's disease) (Whiten et al., 2016) and motor neuron disease-linked proteins SOD1 (Whiten et al., 2016; McAlary et al., 2016) and TDP-43 (Zeineddine et al., 2017a,b). The gene discussed is HTT; the disease is juvenile Huntington disease.