Several murine models of antibody-mediated IFN-I receptor (IFNAR) blockade or genetic ablation of IFN-I signaling (IFNAR1 KO) demonstrated the central pathogenic role played by IFN-I during viral infections (Davidson et al., 2014; Li et al., 2017; Major et al., 2020; Teijaro et al., 2013; Totura et al., 2015; Wilson et al., 2013). This evidence concerns the gene IFNAR1 and viral infectious disease.