In Nlrp3 knockout mice, sepsis can no longer activate the NLRP3 inflammasome, generation of IL‐1ß is much reduced, and activation of NF‐κB as well as NF‐κB signalling is attenuated, which maintains cardiomyocyte size, deformability, contraction and relaxation. Here, NLRP3 is linked to Sepsis.