Although an activation of the NLRP3 inflammasome was reported to mediate cardiac electrical and functional defects in low‐ and medium‐grade sepsis induced by the caecal ligation and puncture (CLP),25 this could not be found in high‐grade polymicrobial sepsis induced by the colon ascendens stent peritonitis (CASP) model.24 The gene discussed is NLRP3; the disease is Sepsis.