Our enrichment analyses demonstrate for the first time that ASF1B may affect the etiology or pathogenesis of cancer by functioning in immune‐related pathways, including those involved in antigen processing and presentation, natural killer cell‐mediated cytotoxicity, regulation of autophagy, autoimmune thyroid disease, and RIG‐I‐like receptor signaling pathway. Here, ASF1B is linked to autoimmune thyroid disease.