In fact, the detrimental role of HO-1 has been demonstratedin leukemia, glioblastoma (GBM), prostate, lung, and colon cancers.6−12 Also, whereas HO-1 is generally found in the cytoplasm, a differentsubcellular localization was detected in cancerous tissues. Here, HMOX1 is linked to malignant colon neoplasm.