In prior work, a mutational frequency of 0.4% was observed for ATM alterations in 7,675 BRCA1 and BRCA2-negative breast cancer patients in a Chinese population [30, 31] and a mutational frequency range of 0.45 to 1.0% was found in the US and Europe [32, 33]. The gene discussed is BRCA2; the disease is breast carcinoma.