DPY19L2 and Infertility: Examination of mouse FAM209-associated proteins detected DPY19L2, a protein that contains ten transmembrane domains, is localized to the inner nuclear envelope and was first found to be implicated in globozoospermia of infertile men ∼10 years ago (Harbuz et al., 2011; Koscinski et al., 2011; Pierre et al., 2012).