DN pathophysiology includes alteration of several molecular pathways, such as oxidative damage, inflammatory responses, apoptosis, protein kinase c (PKC), renin-angiotensin system (RAS) activation, adenosine, toll-like receptor (TLR) activation, transforming growth factor-β (TGF-β), nitric oxide (NO) synthesis, tumor necrosis factor-α (TNF-α), death receptors, JAK/STAT (Janus kinase/signal transducers and activators of transcription) pathway, and different types of adhesion molecules [3, 32]. This evidence concerns the gene TNF and liver dysplastic nodule.