Notably, in a mouse myocardial ischemia/reperfusion injury and MI model, we discovered that proinflammatory IL-6, IL-1β, and TNF-α were remarkably inhibited by IL-37 treatment, while IL-10, an anti-inflammatory cytokine, was significantly upregulated by IL-37 [41, 42]. Here, IL37 is linked to myocardial ischemia.