Bhandari and Kuhad reported that after curcumin treatment at a daily dose of 50, 100, and 200 mg/kg for 4 weeks in rats with propionic acid- (PPA-) induced autism, curcumin restored the core and associated symptoms of autistic phenotype by suppressing oxidative-nitrosative stress, mitochondrial dysfunction, and TNF-α and MMP-9 in PPA-induced autism in rats [73]. This evidence concerns the gene MMP9 and autism.