Based on the regulatory effect of YQHX on post-myocardial infarction neural related factors and myocardial hypertrophy, we observed the expression of ERK1/2 and p-ERK1/2 proteins in the infarct marginal zone of rats after myocardial infarction and the effect of YQHX. Here, MAPK3 is linked to myocardial infarction.