As shown in Figure 2(a), the levels of three proteins (p-PERK, p-elf2α, and ATF-4) in the PERK pathway were significantly reduced when the animals were treated with the PERK inhibitor GSK2606414 after 1 week of IH treatment (P < 0.05 compared with the IH group). The gene discussed is EIF2AK3; the disease is isolated hemihyperplasia.