CASP1 and infection: These differences might be due to differing timepoints and MOIs: Asc–/– BMDMs had slightly reduced IFN-β release 5 h post-infection (MOI, 100)33 and comparable Ifnb mRNA levels 9 h post-infection (MOI, 100)34; Aim2–/– BMDMs had significantly increased IFN-β release 6 h post-infection (MOI, 250)11; and Asc–/– and Casp1/11–/– BMDMs had significantly increased IFN-β release 6 h post-infection (MOI, 50)35.