DNMT3A and neoplasm: The high mutation rate of DNMT3A may eventually lead to impaired biological functions, such as cyanosis, because its protein product affects the transmission of m5C signals in cells, which in turn causes tumor-related phenotype changes such as DNA repair activities and oncogenic tyrosine kinases (such as FLT3ITD, BCR-ABL1, JAK2V617F and MPLW515L) activating mutations.