NOS3 and dentin dysplasia: However, in our present study, mirabegron had beneficial effects on DD characterized by e’ and E/e’, and cardiac fibrosis assessed by histology and left ventricular expressions of Col1a1 and Ctgf. We hypothesized that mirabegron could have its antiremodeling effects independently of the β3-AR-eNOS-mediated pathway in uremic cardiomyopathy.