Interestingly, it has been reported that another ARB, valsartan combined with the neprilysin inhibitor sacubitril (LCZ696) attenuated cardiac hypertrophy and fibrosis in 5/6th nephrectomized rats51 and in human phase I clinical trials in advanced CKD patients with HF (clinical trial No.: NCT03771729 and NCT04218435). This evidence concerns the gene MME and cardiac hypertrophy.