MYC and neoplasm: Moreover, both the fact that AURKA signaling regulates tumor cell metabolism through c-Myc is important and that the response to AURKA inhibitors relies on tumor metabolism (balance between glycolysis and oxidative phosphorylation) via c-Myc is relevant even beyond the current studies given that any treatment modality, involving AURKA inhibitors, will be most likely influenced by the metabolic status of the tumor.