PPARGC1A and glioblastoma: In addition, we considered the mRNA expression of c-Myc and PGC1α in individual tumors (GBM TCGA database, as well as the GBM PDX Mayo Clinic database) and found that high levels of c-Myc were correlated with low levels of PGC1A mRNA in a statistical significant manner (Fig. S10b, c).