While PGC1α had little effect on the oxygen consumption rate in parental SF188 GBM cells, there was a significant reduction in oxidative metabolism in alisertib treated cells, indicating that PGC1α does not appear to play a major role in parental cells, but impacts oxygen consumption in GBM cells exposed to alisertib (Fig. 4p). This evidence concerns the gene PPARGC1A and glioblastoma.