Studies of hepatocellular carcinoma tumor tissues have reported increased abundance of RNA from the Snhg3 locus compared to normal liver tissue that predicts worse clinical outcomes64–66, and gain- and loss- of an SNHG3 cDNA in hepatoma cells impacts proliferation and expression of genes involved in epithelial–mesenchymal transition65–67. The gene discussed is SNHG3; the disease is hepatocellular carcinoma.