Among other downregulated genes were LARS2, a mitochondrial Leucyl t-RNA synthetase gene, known to have an association with hearing loss in human62, CDC25A associated with vision63,64, and UQCRC1 associated with oxidative phosphorylation and known to be downregulated in hypoxic conditions65,66 (Fig. 5d). This evidence concerns the gene UQCRC1 and hearing loss disorder.