GZMB and neoplasm: Indeed, tumour growth control was dependent on anti-tumour CTL response and correlated with an increase in tumour infiltration by proliferative tumour-reactive CD8+ T lymphocytes producing granzyme B. CD8+ T cell-mediated cytotoxicity against the cognate target correlated with upregulation of MHC-I and PD-L1 on B16F10E-KO cells, excluding an association of the beneficial effect with a reduced PD-L1 expression on αV-knockout tumours as previously reported43.