More importantly, quantitative multiplex fluorescent IHC staining using anti-CD8 mAb showed that αVlow tumours were more strongly infiltrated with CD8+ lymphocytes than αVhigh tumours, with a CD8 cell density ranging from 8 to 2103 cells/mm2 and a median of 352 cells/mm2 in αVlow tumours; and from 25 to 436 cells/mm2 and a median of 176 cells/mm2 in αVhigh tumours (p = 0.046; Fig. 1e). The gene discussed is CD8A; the disease is neoplasm.