TP53 and lung carcinoma: Our clinic data showed that combined treatment of RFA + MLT greatly reduced early lung cancer recurrence, which could be explained via our multi-omics analysis with tumor samples in the Control and RFA + MLT groups.41,42 We observed that the P53 pathway was upregulated while the MAPK, NFкB, Wnt, and Hedgehog pathways were downregulated after RFA + MLT treatment.