Six genes, ACSS3, SULT1A2, VTN, LRFN2, NPC1L1, and NEURL3, were identified as being highly significant to AF and having high module membership (Fig. 6f), which existed in the population with an effect (ΔAF ≥ 10) but not in the population with no effect (ΔAF ≤ 0) (Fig. 6e). The gene discussed is NPC1L1; the disease is atrial fibrillation.