Cell populations enriched for KRT14 also exhibited increased IC50 values following cisplatin therapy compared to wild-type or KRT14KO cells and were less susceptible to apoptotic death, suggesting chemo-resistance may be mediated in part via a KRT14-dependent mechanism, and suggests that KRT14 overexpression may contribute in part to acquired chemo-resistance in ovarian cancer patients with the data suggesting that LC abundance is closely related to chemo sensitivity. This evidence concerns the gene KRT14 and ovarian cancer.